Changes in presentation, treatment, and outcomes of adult low-grade gliomas over the past fifty years

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Changes in presentation, treatment, and outcomes of adult low-grade gliomas over the past fifty years.

BACKGROUND To identify changes in patient presentation, treatment, and outcomes of low-grade gliomas (LGGs) over the past 50 years. METHODS Records of 852 adults who received a diagnosis at Mayo Clinic from 1960 through 2011 with World Health Organization grade II LGGs were reviewed and grouped by those who received a diagnosis before (group I: 1960-1989) and after (group II: 1990-2011) the r...

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[Low-grade gliomas: review of 10 years].

INTRODUCTION Central nervous system (CNS) tumors are the most common solid tumors in children. Among these, the low-grade gliomas are the most common type, accounting for up to 30-50% of them. PATIENTS AND METHODS A retrospective analysis was carried out on the epidemiology, clinical characteristics, tumor location, histology, treatment, outcome and long-term sequelae of 111 patients diagnose...

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Outcomes in Reoperated Low-Grade Gliomas.

BACKGROUND Low-grade gliomas (LGGs) comprise a diverse set of intrinsic brain tumors that correlate strongly with survival. Data on the effect of reoperation are sparse. OBJECTIVE To evaluate the effect of reoperation on patients with LGG. METHODS Fifty-two consecutive patients with reoperated LGGs treated at the University of Washington between 1986 and 2004 were identified and evaluated i...

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Multidisciplinary management of adult low grade gliomas.

BACKGROUND Adult hemispheric low grade gliomas (LGG) cover a pathologic spectrum which has specific clinical, histological and molecular characteristics. The optimal management of these tumors is still a controversial topic in international literature. METHODS We evaluated scientific papers from the literature (Medline and Cochrane Library to date) and we compared the results found there with...

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Current treatment of low grade gliomas

Low grade gliomas affect predominantly young adults, and have a relatively favorable prognosis compared to grade III and grade IV gliomas. The challenge for an optimal management of these patients is to find the balance between an optimal survival and the preservation of neurological function including cognition. Because all medical treatments may induce side effects, in young and nearly asympt...

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ژورنال

عنوان ژورنال: Neuro-Oncology

سال: 2013

ISSN: 1522-8517,1523-5866

DOI: 10.1093/neuonc/not080